![]() The work is made available under the Creative Commons CC0public domain dedicationĭata Availability: All data files used to conduct the multistate capture-mark-recapture analysis in MARK are available from the Dryad database doi: 10.5061/dryad.8bq31.įunding: The study was supported by grant CK000170 from the Centers for Diseases Control and Prevention and AI076342 from the National Institute of Allergy and Infectious Diseases, National Institutes of Health (NIAID). This is an open access article, free of all copyright, and may be freely reproduced, distributed, transmitted, modified, built upon, or otherwise used by anyone for any lawful purpose. Received: OctoAccepted: JanuPublished: February 17, 2015 PLoS ONE 10(2):Īcademic Editor: Brian Stevenson, University of Kentucky College of Medicine, UNITED STATES burgdorferi infection risk will facilitate future theoretical studies on the epidemiology of Lyme disease.Ĭitation: Voordouw MJ, Lachish S, Dolan MC (2015) The Lyme Disease Pathogen Has No Effect on the Survival of Its Rodent Reservoir Host. burgdorferi establishes a chronic avirulent infection in their rodent reservoir hosts because this pathogen depends on rodent mobility to achieve transmission to its sedentary tick vector. Our estimates of the probability of infection varied by an order of magnitude (0.051 to 0.535) and were consistent with our understanding of Lyme disease in the Northeastern United States. burgdorferi infection or tick burden on the survival of P. We used a multi-state CMR approach to model mouse survival and mouse infection rates as a function of a variety of ecologically relevant explanatory factors. burgdorferi and its tick vector affect the survival of this important reservoir host. We analyzed four years of capture-mark-recapture (CMR) data on a population of white-footed mice, Peromyscus leucopus, to test whether B. The tick-borne bacterium Borrelia burgdorferi causes Lyme disease in humans but few studies have investigated whether this pathogen reduces the fitness of its reservoir hosts under natural conditions. ![]() Zoonotic pathogens that cause devastating morbidity and mortality in humans may be relatively harmless in their natural reservoir hosts. ![]()
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